Threats from synthetic media, such as deepfakes, present a growing challenge for all users of modern technology and communications, including National Security Systems (NSS), the Department of Defense (DoD), the Defense Industrial Base (DIB), and national critical infrastructure owners and operators. As with many technologies, synthetic media techniques can be used for both positive and malicious purposes. While there are limited indications of significant use of synthetic media techniques by malicious state-sponsored actors, the increasing availability and efficiency of synthetic media techniques available to less capable malicious cyber actors indicate these types of techniques will likely increase in frequency and sophistication.